Marc D McKee Selected Research

Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia)

10/2020	Genetic Ablation of Osteopontin in Osteomalacic Hyp Mice Partially Rescues the Deficient Mineralization Without Correcting Hypophosphatemia.
12/2018	Impaired mineral quality in dentin in X-linked hypophosphatemia.
10/2017	Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia.
1/2017	Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.
1/2016	Expression and inactivation of osteopontin-degrading PHEX enzyme in squamous cell carcinoma.
10/2013	Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia.
3/2013	Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia.
1/2013	MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia.
4/2010	Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage.
10/2008	MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM.

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Marc D McKee Research Topics

Disease

11	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 10/2020 - 12/2002
8	Hypophosphatemia 10/2020 - 12/2002
6	Vascular Calcification 02/2017 - 10/2002
6	Osteomalacia 01/2016 - 06/2008
4	Rickets (Rachitis) 01/2020 - 06/2008
4	Neoplasms (Cancer) 08/2014 - 10/2007
3	Amelogenesis Imperfecta 01/2014 - 04/2008
3	Calcinosis 12/2010 - 04/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 05/2008
2	Kidney Calculi (Kidney Stone) 11/2018 - 08/2009
2	Uremia 02/2017 - 03/2011
2	Hypophosphatasia 10/2013 - 06/2008
2	Obesity 02/2012 - 08/2007
2	Insulin Resistance 02/2012 - 08/2007
2	Glucose Intolerance 02/2012 - 08/2007
2	Hypercalcemia (Milk Alkali Syndrome) 06/2008 - 04/2003
2	Osteonecrosis (Kienbock's Disease) 06/2008 - 10/2007
2	Bone Resorption 09/2005 - 11/2004
1	Congenital Abnormalities (Deformity) 12/2020
1	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome) 01/2020
1	Hyperostosis 01/2020
1	Osteosclerosis 01/2020
1	Arterial calcification of infancy 01/2020
1	Enthesopathy 01/2020
1	Urolithiasis 11/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2017
1	Keutel syndrome 01/2017
1	Craniofacial Abnormalities 01/2017
1	Infections 01/2016
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2016
1	Pathologic Processes 01/2016
1	type 6 Osteogenesis imperfecta 07/2015
1	Polyps 04/2013
1	Abscess 03/2013
1	Type 2 Diabetes Mellitus (MODY) 02/2012
1	Stress Fractures (Stress Fracture) 08/2011
1	Osteogenesis Imperfecta (Lobstein Disease) 07/2011
1	Chondrocalcinosis (Pseudogout) 03/2011
1	Chronic Renal Insufficiency 03/2011
1	Wounds and Injuries (Trauma) 01/2011
1	Shock 08/2008
1	Pyridoxine-dependent epilepsy 06/2008
1	Tooth Loss 05/2008
1	Inflammation (Inflammations) 05/2008
1	Periodontal Diseases (Periodontal Disease) 05/2008
1	Unerupted Tooth 04/2008
1	Osteoporosis 10/2007

Drug/Important Bio-Agent (IBA)

14	OsteopontinIBA 12/2020 - 10/2002
13	MineralsIBA 01/2020 - 09/2005
11	Phosphates (Orthophosphate)IBA 10/2020 - 12/2002
9	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2004
6	Peptides (Polypeptides)IBA 11/2018 - 10/2008
4	EndopeptidasesIBA 01/2016 - 12/2002
3	Vitamin D FDA LinkGeneric 01/2020 - 12/2002
3	Calcium OxalateIBA 11/2018 - 08/2009
3	tuftelin (enamelin)IBA 01/2014 - 04/2008
3	Durapatite (Hydroxylapatite)IBA 04/2010 - 06/2008
2	alpha-2-HS-GlycoproteinIBA 01/2020 - 04/2008
2	Aspartic Acid (Aspartate)FDA Link 11/2018 - 10/2013
2	Serine (L-Serine)FDA Link 11/2018 - 10/2013
2	Matrix Gla ProteinIBA 01/2017 - 10/2002
2	EnzymesIBA 01/2016 - 10/2013
2	Metalloproteases (Metalloproteinases)IBA 01/2016 - 03/2013
2	Alkaline PhosphataseIBA 04/2013 - 06/2008
2	OsteocalcinIBA 02/2012 - 08/2007
2	calcium phosphateIBA 04/2010 - 08/2008
2	Diphosphonates (Bisphosphonates)IBA 06/2008 - 10/2007
1	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)IBA 01/2020
1	ApatitesIBA 02/2017
1	SaltsIBA 01/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	pigment epithelium-derived factorIBA 07/2015
1	IntegrinsIBA 10/2013
1	LigandsIBA 10/2013
1	Glycoproteins (Glycoprotein)IBA 10/2013
1	ZincIBA 03/2013
1	Glucose (Dextrose)FDA LinkGeneric 02/2012
1	kallikrein 4IBA 01/2012
1	Amyloid (Amyloid Fibrils)IBA 01/2012
1	AmelogeninIBA 01/2012
1	Indicators and Reagents (Reagents)IBA 08/2011
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 07/2011
1	SolutionsIBA 03/2011
1	diphosphoric acid (pyrophosphoric acid)IBA 03/2011
1	Fibroblast Growth Factor-23IBA 02/2011
1	CalciumIBA 01/2011
1	Inositol (Myoinositol)IBA 04/2010
1	Dendrimers (Dendrons)IBA 08/2008
1	Glycerol (Glycerine)FDA LinkGeneric 08/2008
1	DNA (Deoxyribonucleic Acid)IBA 08/2008
1	Proteoglycans (Proteoglycan)IBA 06/2008
1	IsoenzymesIBA 06/2008
1	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 06/2008
1	integrin alphavbeta6IBA 05/2008
1	integrin beta6IBA 05/2008
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 05/2008

Therapy/Procedure

3	Therapeutics 02/2017 - 10/2007
1	Injections 02/2012
1	Enzyme Replacement Therapy 06/2008
1	Duration of Therapy 10/2007